New York (3-2) also forced three turnovers, including Chase Blackburn's interception in the end zone midway in the fourth quarter to clinch it.
The Browns are 0-5 for the first time since their return season to the NFL in 1999.
VIKINGS 30, TITANS 7
MINNEAPOLIS (AP) Percy Harvin pounded his way through Tennessee's defense for one touchdown rushing and another receiving for Minnesota.
Harvin caught eight passes for 108 yards for the Vikings (4-1), who have given up a combined 33 points in winning three straight games. Christian Ponder threw his first two interceptions after 143 attempts without one, but he still finished 25 for 35 for 258 yards and two scores against the reeling Titans (1-4).
Matt Hasselbeck, starting in place of the injured Jake Locker, went 26 for 43 for 200 yards, one touchdown and one interception. Most of those gains came near the end with the outcome no longer in doubt.
49ERS 45, BILLS 3
SAN FRANCISCO (AP) Alex Smith threw for a season-high 303 yards and three touchdowns, Frank Gore ran for 106 yards and a score, and San Francisco amassed a franchise-record 621 yards.
Michael Crabtree and Vernon Davis each eclipsed 100 yards receiving to back Smith, who threw TD passes of 43, 28 and 10 yards and surpassed 300 yards passing for only the third time in his career.
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